Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 3 , Pages 91-96 , March 2006

Gene Expression Arrays in Juvenile Rheumatoid Arthritis: Will the Blind Men Finally See the Elephant?

This work was presented, in modified form, at the Pediatric Academic Societies’ Annual Meeting in Washington, DC, May 14th, 2004.

  • James N. Jarvis, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to James N. Jarvis, MD, University of Oklahoma Health Science Center, Division of Rheumatology, Basic Sciences Education Building, Oklahoma City, OK 73105.

References 

  1. Førre Ø , Dobloug JH , Høyerall H , Thorsby E . HLA antigens in juvenile arthritis. Genetic basis for the different subtypes . Arthritis Rheum . 1983;26:35–38
  2. Jarvis JN , Pousak T , Krenz M , Iobidze M , Taylor H . Complement activation and immune complexes in juvenile rheumatoid arthritis . J Rheumatol . 1993;20:114–117
  3. Jarvis JN , Taylor H , Iobidze M , Krenz M . Complement activation and immune complexes in children with polyarticular juvenile rheumatoid arthritis (a longitudinal study) . J Rheumatol . 1994;21:1124–1127
  4. Jarvis JN , Diebold MM , Chadwell MK , Iobidze M , Moore HT . Composition and biological behaviour of immune complexes isolated from synovial fluid of patients with juvenile rheumatoid arthritis . Clin Exp Immunol . 1995;100:514–518
  5. Eberhard BA , Laxer RM , Anderson U , Silverman ED . Local synthesis of both macrophage and T cell cytokines in synovial fluid cells from children with juvenile rheumatoid arthritis . Clin Exp Immunol . 1994;96:260–266
  6. Duby AD , Sinclair AK , Osborne-Lawrence SL , Zeldes W , Kan L , Fox DA . Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis . Proc Natl Acad Sci USA . 1989;86:6206–6210
  7. Struyck L , Hawes GE , Chatila MK , Breedveld FC , Kurnick JT , van den Elsen PJ . T cell receptors in rheumatoid arthritis . Arthritis Rheum . 1995;38:577–589
  8. Lindblad S , Klareskog L , Hedfors E , Forsum U , Sundström C . Phenotypic characterization of synovial tissue cells in situ in different types of synovitis . Arthritis Rheum . 1983;26:1321–1332
  9. Grom AA , Hirsch R . T-cell and T-cell receptor abnormalities in the immunopathogenesis of juvenile rheumatoid arthritis . Curr Opin Rheumatol . 2000;12:420–424
  10. Khalkhali-Ellis Z , Bulla GA , Schlesinger LS , Kirschmann DA , Moore TL , Hendrix MJ . C1q-containing immune complexes purified from sera of juvenile rheumatoid arthritis patients mediate IL-8 production by human synoviocytes (role of C1q receptors) . J Immunol . 1999;163:4612–4620
  11. Van Roon JAG , Lafeber FPJG , Bijlsma JWJ . Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis . Arthritis Rheum . 2001;44:3–12
  12. Fearon DT , Locksley RM . The instructive role of innate immunity in the acquired immune response . Science . 1996;72:50–53
  13. Carroll MC . The role of complement and complement receptors in the regulation of immunity . Ann Rev Immunol . 1998;16:545–568
  14. Warrington KJ , Seisuke T , Goronzy JJ , Weyand CM . CD4+, CD28− T cells in rheumatoid arthritis patients combine features of innate and adaptive immune systems . Arthritis Rheum . 2001;44:13–20
  15. Knowlton N , Dozmorov IM , Centola M . Microarray Data Analysis Toolbox (MDAT) (for normalization, adjustment and analysis of gene expression data) . Bioinformatics . 2004;20:3687–3690
  16. Dozmorov I , Centola M . An associative analysis of gene expression array data . Bioinformatics . 2002;19:204–211
  17. Tezak Z , Hoiffman E , Lutz JL , Fedczyna TO , Stephan D , Bremer EG , et al.   Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis (a novel model of pathogenesis) . J Immunol . 2002;168:4154–4163
  18. Bennett L , Palucka AK , Arce E , Cantrell V , Borvak J , Banchereau J , et al.   Interferon and granulopoiesis signatures in systemic lupus erythematosus blood . J Exp Med . 2004;197:711–723
  19. Jarvis JN , Zospah R , Tang Y , Dozmorov I , Jiang K , Chen Y , et al.   Gene expression arrays exclude immune complex accumulation as a critical factor in the leukocyte activation of polyarticular JRA . Arthritis Rheum . 2004;S363
  20. Jarvis JN , Dozmorov I , Jiang K , Chen Y , Frank MB , Turner S , et al.   Gene expression arrays demonstrate rapid return to normal homeostasis in immunologically-challenged of trophoblast-like JAR cells . J Reprod Immunol . 2004;61:99–113
  21. Jarvis JN , Tang Y , Dozmorov I , et al.   Gene expression arrays reveal chronic, intrinsic activation of neutrophils in children with polyarticular JRA. Is JRA primarily a neutrophil disorder? . Arthritis Rheum . 2004;S443
  22. Dozmorov I , Knowlton N , Tang Y , Shields A , Pathipvanich P , Jarvis JN , et al.   Hypervariable genes—experimental error or hidden dynamics . Nucleic Acids Res . 2004;32:e147
  23. Rantapää-Dahlqvist S , de Jong BAW , Berglin E , Hallmans G , Wadell G , Stenlund H , et al.   Antibodies against cyclic citrullinated peptide (CCP) and immunoglobulin-A rheumatoid factor predict the development of rheumatoid arthritis . Arthritis Rheum . 2003;10:2741–2749
  24. Berglin E , Padyukov L , Sundin U , Hallmans G , Stenlund H , Van Venrooij WJ , et al.   A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis . Arthritis Res Ther . 2004;6:R303–R308
  25. Arbuckle MR , McClain MT , Rubertone MV , Scofield RH , Dennis GJ , James JA , et al.   Development of autoantibodies before the clinical onset of systemic lupus erythematosus . N Eng J Med . 2003;349:1526–1533
  26. McClain MT , Heinlen LD , Dennis GJ , Roebuck J , Harley JB , James JA . Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry . Nat Med . 2005;11:85–89
  27. Jarvis JN . Juvenile rheumatoid arthritis (a guide for pediatricians) . Pediatr Ann . 2002;31:437–446
  28. Morand EF , Bucala R , Leech M . Macrophage migration inhibitory factor (an emerging therapeutic target in rheumatoid arthritis) . Arthritis Rheum . 2003;48:291–299
  29. Barnes MG , Aronow BJ , Luyrink LK , Moroldo MB , Pavlidis P , Passo MH , et al.   Gene expression in juvenile arthritis and spondyloarthropathy (pro-angiogenic ELR+ chemokine genes relate to course of arthritis) . Rheumatology . 2004;43:973–979
  30. Jarvis JN , Dozmorov I , Jiang K , Frank MB , Szodoray P , Alex P , et al.   Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis . Arthritis Res Ther . 2004;R15–R32
  31. Cleland LG , James MJ , Proudman SM . Omega-6/omega-3 fatty acids and arthritis . World Rev Nutr Diet . 2003;92:152–168
  32. Simopoulos AP . Omega-3 fatty acids in inflammation and autoimmune diseases . J Am Coll Nutr . 2002;21:495–505
  33. Homaidan FR , Chakroun I , Haidar HA , El-Sabban ME . Protein regulators of eicosanoid synthesis (role in inflammation) . Curr Protein Peptide Sci . 2002;320:467–484
  34. Martinon F , Tschopp J . Inflammatory caspases (linking an intracellular innate immune system to autoinflammatory diseases) . Cell . 2004;117(5):561–574
  35. Dozmorov I , Knowlton N , Tang Y , Shields A , Pathipvanich P , Jarvis JN , et al.   Hypervariable genes—experimental error or hidden dynamics . Nucleic Acids Res . 2004;32:e147
  36. Hitchon CA , Alex P , Erdile LB , Frank MB , Dozmorov I , Tang Y , et al.   A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis . J Rheumatol . 2004;31:2336–2346
  37. McGhee JL , Burks F , Sheckels J , Jarvis JN . Identifying children with chronic arthritis based on chief complaints (absence of predictive value for musculoskeletal pain as an indicator of rheumatic disease in children) . Pediatrics . 2002;110:354–359
  38. McGhee JL , Kickingbird L , Jarvis JN . Clinical utility of ANA tests in children . BMC Pediatr . 2004;4:13
  39. Olsen NJ , Sokka T , Seehorn CL , Kraft B , Moore J , Aune TM . A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells . Ann Rheum Dis . 2004;63:1387–1392
  40. Jarvis JN , Centola M . Gene expression profiling (time for entry into the clinical arena?) . Lancet . 2005;325:199–200

 This work was supported by grant R21-AR-48378.

PII: S1538-5442(05)00130-6

doi: 10.1016/j.cppeds.2005.10.010

Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 3 , Pages 91-96 , March 2006

Article Tools

* Image Usage & Resolution