Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 5 , Pages 189-204 , May 2006

Newborn Immunology: Relevance to the Clinician

  • David B. Lewis

      Affiliations

    • Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
    • ,
  • James E. Gern

      Affiliations

    • Department of Pediatrics, University of Wisconsin Medical School, Madison, WI
    • ,
  • Harry R. Hill

      Affiliations

    • Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Samuel L. Friedlander

      Affiliations

    • Department of Pediatrics, University of Wisconsin Medical School, Madison, WI
    • ,
  • Timothy R. La Pine

      Affiliations

    • Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Robert F. Lemanske Jr

      Affiliations

    • Department of Pediatrics, University of Wisconsin Medical School, Madison, WI
    • ,
  • E. Richard Stiehm

      Affiliations

    • Department of Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA

References 

  1. Lewis DB , Wilson CB . Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection . In:  Remington JS ,  Klein JO ,  Baker C , et al. editor. Infectious diseases of the fetus and the newborn infant . 6th ed.. Philadelphia: Saunders/Elsevier; 2005;p. 87–210
  2. Watts C . The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules . Nat Immunol . 2004;5:685–692
  3. Berenson LS , Ota N , Murphy KM . Issues in T-helper 1 development—resolved and unresolved . Immunol Rev . 2004;202:157–174
  4. Quezada SA , Jarvinen LZ , Lind EF , et al.   CD40/CD154 interactions at the interface of tolerance and immunity . Annu Rev Immunol . 2004;22:307–328
  5. Frucht DM , Fukao T , Bogdan C , et al.   IFN-gamma production by antigen-presenting cells (mechanisms emerge) . Trends Immunol . 2001;22:556–560
  6. Picard C , Casanova JL . Inherited disorders of cytokines . Curr Opin Pediatr . 2004;16:648–658
  7. van den Elsen PJ , Holling TM , Kuipers HF , et al.   Transcriptional regulation of antigen presentation . Curr Opin Immunol . 2004;16:67–75
  8. Wong GH , Goeddel DV . Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons . Nature . 1986;323:819–822
  9. Seo SH , Hoffmann E , Webster RG . Lethal H5N1 influenza viruses escape host anti-viral cytokine responses . Nat Med . 2002;8:950–954
  10. O’Sullivan B , Thomas R . CD40 and dendritic cell function . Crit Rev Immunol . 2003;23:83–107
  11. Ameratunga R , Lederman HM , Sullivan KE , et al.   Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome . J Pediatr . 1997;131:147–150
  12. Jain A , Atkinson TP , Lipsky PE , et al.   Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome . J Clin Invest . 1999;103:1151–1158
  13. Grewal IS , Borrow P , Pamer EG , et al.   The CD40-CD154 system in anti-infective host defense . Curr Opin Immunol . 1997;9:491–497
  14. Bevan MJ . Helping the CD8+ T-cell response . Nat Rev Immunol . 2004;4:595–602
  15. Catalfamo M , Henkart PA . Perforin and the granule exocytosis cytotoxicity pathway . Curr Opin Immunol . 2003;15:522–527
  16. Lee HO , Ferguson TA . Biology of FasL . Cytokine Growth Factor Rev . 2003;14:325–335
  17. Appay V , Dunbar PR , Callan M , et al.   Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections . Nat Med . 2002;8:379–385
  18. Radosevich TJ , Seregina T , Link CJ . Effective suppression of class I major histocompatibility complex expression by the US11 or ICP47 genes can be limited by cell type or interferon-gamma exposure . Hum Gene Ther . 2003;14:1765–1775
  19. Mellman I , Steinman RM . Dendritic cells (specialized and regulated antigen processing machines) . Cell . 2001;10:255–258
  20. Hemmi H , Akira S . TLR signalling and the function of dendritic cells . Chem Immunol Allergy . 2005;86:120–135
  21. Dabbagh K , Dahl ME , Stepick-Biek P , et al.   Toll-like receptor 4 is required for optimal development of Th2 immune responses (role of dendritic cells) . J Immunol . 2002;168:4524–4530
  22. Housset D , Malissen B . What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? . Trends Immunol . 2003;24:429–437
  23. Chen L , Cohen AC , Lewis DB . Impaired allogeneic activation and T-helper 1 differentiation of human cord blood naive CD4 T cells . Biol Blood Marrow Transplant . 2006;12:160–171
  24. Trinchieri G . Interleukin-12 and the regulation of innate resistance and adaptive immunity . Nat Rev Immunol . 2003;3:133–146
  25. Kaminski BA , Kadereit S , Miller RE , et al.   Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation . Blood . 2003;102:4608–4617
  26. West DJ . Clinical experience with hepatitis B vaccines . Am J Infect Control . 1989;17:172–180
  27. Whitley RJ . Herpes simplex virus infections of women and their offspring (implications for a developed society) . Proc Natl Acad Sci USA . 1994;91:2441–2447
  28. Kimberlin DW . Neonatal herpes simplex infection . Clin Microbiol Rev . 2004;17:1–13
  29. Herget GW , Riede UN , Schmitt-Graff A , et al.   Generalized herpes simplex virus infection in an immunocompromised patient—report of a case and review of the literature . Pathol Res Pract . 2005;201:123–129
  30. Burchett SK , Weaver WM , Westall JA , et al.   Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes . J Immunol . 1988;140:3473–3481
  31. Sullender WM , Miller JL , Yasukawa LL , et al.   Humoral and cell-mediated immunity in neonates with herpes simplex virus infection . J Infect Dis . 1987;155:28–37
  32. Tu W , Chen S , Sharp M , et al.   Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children . J Immunol . 2004;172:3260–3267
  33. Chen SF , Tu WW , Sharp MA , et al.   Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood . J Infect Dis . 2004;189:1619–1627
  34. Stagno S . Cytomegalovirus . In:  Remington JS ,  Klein JO editor. Infectious diseases of the fetus and newborn infant . 5th ed.. Philadelphia: W.B. Saunders; 2001;p. 389–424
  35. Marchant A , Appay V , Van Der Sande M , et al.   Mature CD8(+) T lymphocyte response to viral infection during fetal life . J Clin Invest . 2003;111:1747–1755
  36. Cherry JD . Enteroviruses . In:  Remington JS ,  Klein JO ,  Baker C , et al. editor. Infectious diseases of the fetus and newborn . 5th ed.. Philadelphia: W.B. Saunders; 2001;p. 477–518
  37. Lin TY , Kao HT , Hsieh SH , et al.   Neonatal enterovirus infections (emphasis on risk factors of severe and fatal infections) . Pediatr Infect Dis J . 2003;22:889–894
  38. Remington JS , McLeod R , Thulliez P , et al.   Toxoplasmosis . In:  Remington JS ,  Klein JO editor. Infectious diseases of the fetus and newborn infant . 5th ed.. Philadelphia: W.B. Saunders; 2001;p. 205–346
  39. de Repentigny L , Lewandowski D , Jolicoeur P . Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection . Clin Microbiol Rev . 2004;17:729–759
  40. Smith S , Jacobs RF , Wilson CB . The immunobiology of childhood tuberculosis (a window on the ontogeny of cellular immunity) . J Pediatr . 1997;131:16–26
  41. Marchant A , Goetghebuer T , Ota MO , et al.   Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination . J Immunol . 1999;163:2249–2255
  42. Vekemans J , Amedei A , Ota MO , et al.   Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes . Eur J Immunol . 2001;3:1531–1535
  43. Jones JM , Gellert M . The taming of a transposon (V(D)J recombination and the immune system) . Immunol Rev . 2004;200:233–248
  44. Hazenberg MD , Verschuren MC , Hamann D , et al.   T cell receptor excision circles as markers for recent thymic emigrants (basic aspects, technical approach, and guidelines for interpretation) . J Mol Med . 2001;79:631–640
  45. Chan K , Puck JM . Development of population-based newborn screening for severe combined immunodeficiency . J Allergy Clin Immunol . 2005;115:391–398
  46. McGhee SA , Stiehm ER , McCabe ERB . Potential costs and benefits of newborn screening for severe combined immunodeficiency . J Pediatr . 2005;147:603–608
  47. Lewis DB , Larsen A , Wilson CB . Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation . J Exp Med . 1986;163:1018–1023
  48. Prescott SL , Macaubas C , Holt BJ , et al.   Transplacental priming of the human immune system to environmental allergens (universal skewing of initial T cell responses toward the Th2 cytokine profile) . J Immunol . 1998;160:4730–4737
  49. Halonen M , Martinez FD . A deficient capacity to produce interferon-gamma (is it a risk for asthma and allergies?) . Clin Exp Allergy . 1997;27:1234–1236
  50. Prescott SL . Early origins of allergic disease (a review of processes and influences during early immune development) . Curr Opin Allergy Clin Immunol . 2003;3:125–132
  51. Tang MLK , Kemp AS , Thorburn J , et al.   Reduced interferon-γ production in neonates and subsequent atopy . Lancet . 1994;344:983–985
  52. Miles EA , Warner JA , Jones AC , et al.   Peripheral blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents . Clin Exp Allergy . 1996;2:780–788
  53. Williams TJ , Jones CA , Miles EA , et al.   Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms . J Allergy Clin Immunol . 2000;105:951–959
  54. van der Pouw Kraan TCTM , Boeije LCM , de Groot ER , et al.   Reduced production of IL-12 and IL-12-dependent IFN-g release in patients with allergic asthma . J Immunol . 1997;158:5560–5565
  55. Koning H , Neijens HJ , Baert MR , et al.   T cell subsets and cytokines in allergic and non-allergic children. I. Analysis of IL-4, IFN-gamma and IL-13 mRNA expression and protein production . Cytokine . 1997;9:416–426
  56. Nakao F , Ihara K , Kusuhara K , et al.   Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma . J Allergy Clin Immunol . 2001;107:499–504
  57. Rowe J , Heaton T , Kusel M , et al.   High IFN-gamma production by CD8+ T cells and early sensitization among infants at high risk of atopy . J Allergy Clin Immunol . 2004;113:710–716
  58. Lemanske RF . The childhood origins of asthma (COAST) study . Pediatr Allergy Immunol . 2002;13(Suppl 15):38–43
  59. Neaville WA , Tisler C , Anklam K , et al.   Developmental cytokine response profiles and the clinical and immunologic expression of atopy in infancy . J Allergy Clin Immunol . 2003;112:740–746
  60. Gern JE , Martin MS , Anklam KA , et al.   Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy . Pediatr Allergy Immunol . 2002;13:386–393
  61. Hoffjan S , Ostrovnaja I , Nicolae D , et al.   Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy . J Allergy Clin Immunol . 2003;113:511–518
  62. Strachan DP . Hay fever, hygiene, and household size . BMJ . 1989;299:1259–1260
  63. Bufford JD , Gern JE . The hygiene hypothesis revisited . Immunol Allergy Clin North Am . 2005;25:247–262
  64. Lemanske RF , Jackson DJ , Gangnon RE , et al.   Rhinovirus illnesses during infancy predict subsequent childhood wheezing . J Allergy Clin Immunol . 2005;116:571–577
  65. Copenhaver CC , Gern JE , Li Z , et al.   Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life . Am J Respir Crit Care Med . 2004;170:175–180
  66. Gern JE , Reardon CL , Hoffjan S , et al.   Effects of dog ownership and genotype on immune development and atopy in infancy . J Allergy Clin Immunol . 2004;113:307–314
  67. Hemming VG , Hall RT , Rhodes PG , et al.   Assessment of group B streptococcal opsonins in human and rabbit serum by neutrophil chemiluminescence . J Clin Invest . 1976;58:1379–1387
  68. Shigeoka AO , Hall RT , Hill HR . Blood-transfusion in group B streptococcal sepsis . Lancet . 1978;1:636–638
  69. Santos JI , Shigeoka AO , Rote NS , et al.   Protective efficacy of a modified immune serum globulin in experimental group B streptococcal infection . J Pediatr . 1981;99:873–879
  70. Christensen RD , Hardman T , Thornton J , et al.   A randomized, double-blind placebo-controlled investigation of the safety of intravenous immune globulin administration to preterm neonates . J Perinatol . 1989;9:126–130
  71. Hill HR , Shigeoka AO , Pincus S , et al.   Intravenous IgG in combination with other modalities in the treatment of neonatal infections . Pediatr Infect Dis J . 1986;5:S180–S184
  72. Hill HR , Yang KD , Shigeoka AO , et al.   Intravenous immunoglobulin use in newborns . Clin Immunol Allergy . 1989;84:617–624
  73. Hill HR . Intravenous immunoglobulin use in the neonate (role in prophylaxis and therapy of infection) . Pediatr Infect Dis J . 1993;12:549–559
  74. Hill HR . Additional confirmation of the lack of effect of intravenous immunoglobulin in the prevention of neonatal infection . J Pediatr . 2000;137:595–597
  75. Jenson HB , Pollock BH . Meta-analyses of the effectiveness of intravenous immune globulin for prevention and treatment of neonatal sepsis . Pediatrics . 1997;99(2):E2
  76. Kim KS . Efficacy of human immunoglobulin and penicillin G in treatment of group B streptococcal infection . Pediatr Res . 1987;21:289–292
  77. Christensen RD , Rothstein G . Exhaustion of mature marrow neutrophils in neonates with sepsis . J Pediatr . 1980;96:316–318
  78. Christensen RD , Shigeoka AO , Hill HR , et al.   Neutropenia and bone marrow exhaustion in human and experimental neonatal sepsis . Pediatr Res . 1980;14:806–808
  79. Christensen RD , MacFarlane JL , Taylor NL , et al.   Blood and marrow neutrophils during experimental group B streptococcal infection (quantification of the stem cell, proliferative, storage and circulating pools) . Pediatr Res . 1982;16:549–553
  80. Laurenti F , Ferro R , Isacchi G , et al.   Polymorphonuclear leukocyte transfusion for the treatment of sepsis in the newborn infant . J Pediatr . 1981;98:118
  81. Christensen RD , Rothstein G , Bradley P , et al.   Granulocyte transfusions increase survival in neonates with sepsis and neutrophil depletion . Pediatr Res . 1981;15:608
  82. Hill HR . Phagocyte transfusion—ultimate therapy of neonatal disease? . J Pediatr . 1981;98:59–61
  83. Hill HR . Granulocyte transfusions in neonates . Pediatr Rev . 1991;12:298–302
  84. Cairo MS , Worcester CVC , Rucker RW , et al.   Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for a neonatal neutropenia and sepsis . J Pediatr . 1992;120:281–285
  85. Christensen RD , Brown MS , Hall DC , et al.   Effect of IVIG administration to neonates with clinical signs of early-onset sepsis on neutrophil kinetics and serum opsonic capacity . J Pediatr . 1991;118:606–614
  86. Shigeoka AO , Gobel RJ , Janatova J , et al.   Neutrophil mobilization induced by complement fragments during experimental group B streptococcal infection . Am J Pathol . 1988;33:623–629
  87. Hill HR , Gonzales LA , Knappe WA , et al.   Comparative protective activity of human monoclonal and hyperimmune polyclonal antibody against group B streptococci . J Infect Dis . 1991;163:792–798
  88. Shyur SD , Raff HV , Bohnsack JF , et al.   Comparison of the opsonic and complement triggering activity of human monoclonal IgG1 and IgM antibody against group B streptococci . J Immunol . 1992;148:1879–1884
  89. Schibler KR , Liechty KW , White WL , et al.   Production of granulocyte colony-stimulating factor in vitro by monocytes from preterm and term neonates . Blood . 1993;82:2478–2484
  90. Bernstein HM , Calhoun DA , Christensen RD . Use of myeloid colony-stimulating factors in neonates with septicemia . Curr Opin Pediatr . 2002;14:91–94
  91. Carr R , Modi N , Dore C . G-CSF and GM-CSF for treating or preventing neonatal infections. Vol. 1. The Cochrane Library . New York: John Wiley & Sons, Ltd; 2005; 1-30.
  92. Bryson YJ , Winter HS , Gard SE , et al.   Deficiency of immune interferon production by leukocytes of normal newborns . Cell Immunol . 1980;55:191–200
  93. Lewis DB , Larsen A , Wilson CB . Reduced interferon-γmRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation . J Exp Med . 1986;163:1018–1023
  94. Lewis DB , Weaver M , Prickett K , et al.   Restricted production of IL4 compared to IFN-gamma by human T cells during postnatal development . J Cell Biochem . 1989;13(A):233
  95. Joyner JL , Augustine NA , La Pine TR , et al.   Effects of group B streptococci on cord and adult mononuclear cell transcription and translation of IL-12 and IFN-γ . J Infect Dis . 2000;182:974–977
  96. La Pine TR , Joyner JL , Augustine NH , et al.   Defective production of IL-18 and IL-12 by cord blood mononuclear cells influences the T helper-1 interferon gamma response to group B streptococci . Pediatr Res . 2003;54:276–281
  97. Hill HR , Augustine NH , Jaffe HS . Human recombinant interferon gamma enhances neonatal PMN activation and movement and increases free intracellular calcium . J Exp Med . 1991;173:767–770
  98. La Pine TR , Wiest DJ , Augustine NH , et al.   T-helper-1 cytokines and neutrophil function in neonatal host defense . J Invest Med . 2005;53:S153
  99. La Pine TR , Wiest DJ , Augustine NH , et al.   T-helper-1 cytokines and neutrophil function in neonatal host defense . PAS Progr Abstr . 2005;57:156

 Supported by NIH grants RO1-HL6181879-01, RO1-HL70831-01, and 5MO1-RR03186-18.

PII: S1538-5442(05)00133-1

doi: 10.1016/j.cppeds.2005.11.001

Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 5 , Pages 189-204 , May 2006

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