Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 9 , Pages 318-331 , October 2006

Traumatic Brain Injury: A Primer for Primary Care Physicians

References 

  1. National Centers for Injury Prevention and Control . Traumatic brain injury in the United States: assessing outcomes in children . Atlanta GA: Centers for Disease Control and Prevention; 2003; Retrieved from www.cdc.gov, December 2005.
  2. Tilford JM , Aitken ME , Anand JS , Green JW , Goodman AC , Parker JG , et al.   Hospitalizations for critically ill children with traumatic brain injuries: a longitudinal analysis . Crit Care Med . 2005;33:2074–2081
  3. Goldstein B . Severe traumatic brain injury in children: the good, the bad, and the ugly . Crit Care Med . 2005;33:2140–2141
  4. Holmes JF , Palchak MJ , MacFarlane T , Kupperman N . Performance of pediatric Glasgow coma scale in children with blunt head trauma . Acad Emerg Med . 2005;12:814–819
  5. Han CY , Backous DD . Basic principles of cerebrospinal fluid metabolism and intracranial pressure homeostasis . Otolaryngol Clin North Am . 2005;38:569–576
  6. Vincent JL , Berre J . Primer on medical management of severe brain injury . Crit Care Med . 2005;33:1392–1399
  7. Bayir H , Kochanek PM , Clark RS . Traumatic brain injury in infants and children—mechanisms of secondary damage and treatment in the intensive care unit . Crit Care Clin . 2003;19:529–549
  8. Vivilala MS , Lee LA , Boddu K , Visco E , Newell DW , Zimmerman J , et al.   Cerebral autoregulation in pediatric traumatic brain injury . Pediatr Crit Care Med . 2004;5:257–263
  9. Adelson PD , Clyde B , Kochanek PM , et al.   Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report . Pediatr Neurosurg . 1997;26:200–207
  10. Ruppel RA , Kochanek PM , Adelson PD , et al.   Endothelin-1 is increased in cerebrospinal fluid following traumatic brain injury in children . Abstr Soc Neurosci . 2000;26:1325
  11. Kochanek PM , Clark RS , Ruppel RA , et al.   Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe TBI in infants and children: Lessons learned from the bedside . Pediatr Crit Care Med . 2000;1:4–19
  12. Kennedy CS , Moffatt M . Acute traumatic brain injury in children: exploring the cutting edge in understanding, therapy and research . Clin Pediatr Emerg Med . 2004;5:224–238
  13. Ruppel RA , Kochanek PM , Adelson PO , et al.   Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse . J Pediatr . 2001;138:18–25
  14. Ruppel RA , Clark RS , Bayir H , et al.   Critical mechanisms of secondary injury damage after inflicted head injury in infants and children . Neurosurg Clin North Am . 2002;13:169–182
  15. Shore PM , Jackson EK , Wisniewski SR , et al.   Vascular endothelial growth factor is increased in cerebrospinal fluid after TBI in infants and children . Neurosurgery . 2004;54:605–612
  16. Morris GF , Bullock R , Marshall SB , et al.  The Selfotel Investigators   Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials . J Neurosurg . 1999;91:737–743
  17. Clark RS , Kochanek PM , Adelson PD , et al.   Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury . J Pediatr . 2000;137:197–204
  18. Clark RSB , Kochanek PM , Obrist WD , et al.   Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans . Crit Care Med . 1996;24:1243–1251
  19. Lenzlinger PM , Morganti-Kossmann MC , Laurer HL , et al.   The duality of the inflammatory response to traumatic brain injury . Mol Neurobiol . 2001;24:169–181
  20. Palchak MJ , Holmes JF , Vance CW , Gelber RE , Schauer BA , Harrison MJ , et al.   A decision rule for identifying children at low risk for brain injuries after blunt head trauma . Ann Emerg Med . 2003;42:492–506
  21. Halley MK , Silva PD , Foley J , et al.   Loss of consciousness: when to perform computed tomography . Pediatr Crit Care Med . 2004;5:230–233
  22. Marshall LF , Bowers Marshall S , Klauber MR , Clark M , Eisenberg H , Jane J , et al.   The diagnosis of head injury requires a classification based on computed axial tomography . J Neurotrauma . 1992;9(Suppl. 1):S287–S291
  23. Herrmann M , Jost S , Kutz S , et al.   Temporal profile of release of neurobiochemical markers of brain damage after TBI is associated with intracranial pathology as demonstrated in cranial computerized tomography . J Neurotrauma . 2000;17:113–122
  24. Pleines UE , Morganti-Kossmann MC , Rancan M , et al.   S-100B reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe TBI . J Neurotrauma . 2001;18:491–498
  25. Adelson PD , Bratton SL , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents . Crit Care Med . 2003;31:S417–S488
  26. Adelson PD , Bratton SL , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 2: Trauma systems, pediatric trauma centers, and the neurosurgeon) . Crit Care Med . 2003;31:S421–S423
  27. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 4: Resuscitation of blood pressure and oxygenation and pre-hospital brain specific therapies for the severe pediatric traumatic brain injury patient) . Crit Care Med . 2003;31:S428–S434
  28. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 5: Indications for intracranial pressure monitoring in pediatric patients with severe traumatic brain injury) . Crit Care Med . 2003;31:S435–S439
  29. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 6: Threshold for treatment of intracranial hypertension) . Crit Care Med . 2003;31:S441–S443
  30. Chambers IR , Kirkham FJ . What is the optimal cerebral perfusion pressure in children suffering from traumatic coma? . Neurosurgery Focus . 2003;15(6):
  31. Alberico AM , Ward JD , Choi SC , et al.   Outcome after severe head injury (Relationship to mass lesions, diffuse injury and intracranial pressure course in pediatric and adult patients) . J Neurosurg . 1987;67:648–656
  32. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 12: Use of hyperventilation in the acute management of severe pediatric traumatic brain injury) . Crit Care Med . 2003;31:S461–S464
  33. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 7: Intracranial pressure monitoring technology) . Crit Care Med . 2003;31:S444–S446
  34. Dias MS . Traumatic brain and spinal cord injury . Pediatr Clin North Am . 2004;51:271–303
  35. King BS , Gupta R , Narayan RK . The early assessment and intensive care unit management of patients with severe traumatic brain and spinal cord injuries . Surg Clin North Am . 2000;80:855–870 viii-ix.
  36. Khanna S , David D , Peterson B , Fisher B , Tung H , O’Quigley J , et al.   Use of hypertonic saline in the treatment of severe refractory post-traumatic intracranial hypertension in pediatric traumatic brain injury . Crit Care Med . 2000;28:1144–1151
  37. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 11: Use of hyperosmolar therapy in the management of severe pediatric traumatic brain injury) . Crit Care Med . 2003;31:S456–S460
  38. Bayir H , Clark RS , Kochanek PM . Promising strategies to minimize secondary brain injury after head trauma . Crit Care Med . 2003;31:S112–S117
  39. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 19: The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury) . Crit Care Med . 2003;31:S488–S490
  40. Adelson PD , Carney NA , Chesnut RM , duCondray HE , Goldstein B , et al.   Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents (Chapter 17: Critical pathway for the treatment of established intracranial hypertension in pediatric traumatic brain injury) . Crit Care Med . 2003;31:S481–S483
  41. Bulger EM , Nathens AB , Rivara FP , Moore M , MacKenzie EJ , Jurkovich GJ , et al.   Management of severe head injury: institutional variations in care and effect on outcome . Crit Care Med . 2002;30:1870–1876
  42. Hackbarth RM , Rzeszutko KM , Sturm G , Denders J , Kuldanek AS , SanFilippo DJ . Survival and functional outcome in pediatric traumatic brain injury: a retrospective review and analysis of predictive factors . Crit Care Med . 2002;30:1630–1635
  43. National Center for Injury Prevention and Control, Division of Injury and disability Outcomes and Programs . Traumatic Brain Injury in the United States: Assessing Outcomes in Children . Atlanta, GA: Centers for Disease Control and Prevention; 2003; Retrieved from www.cdc.gov, March 2006.
  44. Polin RS , Shaffrey ME , Bogaev CA , et al.   Decompressive bifrontal craniectomy in the treatment of severe refractory post traumatic cerebral edema . Neurosurgery . 1997;41:84–92
  45. Duhaime AC , Christian CW , Rorke LB , Zimmerman RA . Nonaccidental head injury in infants—the “shaken-baby syndrome . ” New Engl J Med . 1998;338:1822–1829
  46. Lane WG . Diagnosis and management of physical abuse in children . Clin Family Prac . 2003;5:493–514

PII: S1538-5442(06)00060-5

doi: 10.1016/j.cppeds.2006.05.004

Current Problems in Pediatric and Adolescent Health Care
Volume 36, Issue 9 , Pages 318-331 , October 2006